HRASLS2 Antibody (PACO19781)
- SKU:
- PACO19781
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HRASLS2 Antibody (PACO19781) |
| Antibody SKU: | PACO19781 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human HRASLS2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19781(HRASLS2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19781(HRASLS2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | HRASLS2 (HRAS-like suppressor 2), also known as PLA1/2-2, is a 162 amino acid, cytoplasmic protein that belongs to the H-rev107 family. Expressed in liver, kidney, small intestine and colon, HRASLS2 exhibits PLA1/2 activity by catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PCs) and phosphatidylethanolamine (PE). |
| Synonyms: | HRAS-like suppressor 2 |
| UniProt Protein Function: | H1R: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-passChromosomal Location of Human Ortholog: 3p25Cellular Component: nucleoplasm; integral to plasma membrane; cytoplasm; plasma membraneMolecular Function: G-protein coupled receptor activity; histamine receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; positive regulation of vasoconstriction; eosinophil chemotaxis; regulation of synaptic plasticity; visual learning; positive regulation of inositol trisphosphate biosynthetic process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vascular permeability; inflammatory response; memory |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q9NWW9 |
| NCBI GenInfo Identifier: | 8923526 |
| NCBI Gene ID: | 54979 |
| NCBI Accession: | NP_060348 |
| UniProt Secondary Accession: | Q9NWW9,Q9NWW9 |
| UniProt Related Accession: | Q9NWW9 |
| Molecular Weight: | 56 |
| NCBI Full Name: | phospholipase A and acyltransferase 2 |
| NCBI Synonym Full Names: | phospholipase A and acyltransferase 2 |
| NCBI Official Symbol: | PLAAT2 |
| NCBI Official Synonym Symbols: | HRASLS2; PLAAT-2; PLA1/2-2 |
| NCBI Protein Information: | phospholipase A and acyltransferase 2 |
| UniProt Protein Name: | Histamine H1 receptor |
| UniProt Synonym Protein Names: | |
| Protein Family: | Histamine H1 receptor |
| UniProt Gene Name: | HRH1 |
| UniProt Entry Name: | HRH1_HUMAN |
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