HP1 gamma/CBX3 Polyclonal Antibody
- SKU:
- CAB24298
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | HP1 gamma/CBX3 Polyclonal Antibody |
| Product Code: | CAB24298 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human HP1 gamma/CBX3 (NP_009207.2). |
| Sequence: | MASNK TTLQK MGKKQ NGKSK KVEEA EPEEF VVEKV LDRRV VNGKV EYFLK WKGFT DADNT WEPEE NLDCP ELIEA FLNSQ KAGKE KDGTK RKSLS DSESD DSKSK KKRDA ADKPR GFARG LDPER IIGAT DSSGE LMFLM KWKDS DEADL VLAKE ANMKC PQIVI AFYEE RLTWH SCPED EAQ |
| Synonyms: | HECH, HP1-GAMMA, HP1Hs-gamma |
| Calculated MW: | 21kDa |
| Observed MW: | Refer to figures |
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