Name: HOXA11/HOXD11 Antibody (PACO23443)
SKU: PACO23443
Availability: OutOfStock

Antibody Name:	HOXA11/HOXD11 Antibody (PACO23443)
Antibody SKU:	PACO23443
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human HOXA11/D11.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extracts from RAW264.7 cells, using HOXA11/D11 antibody.
	Immunofluorescence analysis of HUVEC cells, using HOXA11/D11 antibody.

Background:	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Synonyms:	Homeobox protein Hox-A11; Hox-1I; HOXA11; HOX1I;

UniProt Protein Function:	HOXA11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT). The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Belongs to the Abd-B homeobox family.
UniProt Protein Details:	Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 7p15.2 Cellular Component: transcription factor complex; protein complex; nucleus Molecular Function:sequence-specific DNA binding Biological Process: embryonic forelimb morphogenesis; developmental growth; anatomical structure morphogenesis; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; male gonad development; uterus development; anterior/posterior pattern formation; positive regulation of chondrocyte differentiation; dorsal/ventral pattern formation; ureteric bud branching; single fertilization; induction of an organ; mesodermal cell fate specification; spermatogenesis; embryonic digit morphogenesis; skeletal development; metanephros development; proximal/distal pattern formation; embryonic limb morphogenesis Disease: Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia
NCBI Summary:	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
UniProt Code:	P31270
NCBI GenInfo Identifier:	13124744
NCBI Gene ID:	3207
NCBI Accession:	P31270.2
UniProt Related Accession:	P31270
Molecular Weight:
NCBI Full Name:	Homeobox protein Hox-A11
NCBI Synonym Full Names:	homeobox A11
NCBI Official Symbol:	HOXA11
NCBI Official Synonym Symbols:	HOX1; HOX1I; RUSAT1
NCBI Protein Information:	homeobox protein Hox-A11
UniProt Protein Name:	Homeobox protein Hox-A11
UniProt Synonym Protein Names:	Homeobox protein Hox-1I
UniProt Gene Name:	HOXA11
UniProt Entry Name:	HXA11_HUMAN