HOMER3 Antibody (PACO41414)
- SKU:
- PACO41414
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HOMER3 Antibody (PACO41414) |
| Antibody SKU: | PACO41414 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Homer protein homolog 3 protein (151-361AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: HOMER3 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 17, 14, 36 kDa. Observed band size: 40 kDa. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO41414 at dilution of 1:100. |
| Background: | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. |
| Synonyms: | Homer protein homolog 3 (Homer-3), HOMER3 |
| UniProt Protein Function: | HOMER3: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Belongs to the Homer family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19p13.11Cellular Component: postsynaptic membrane; cytoplasm; plasma membrane; cell junction; cytosolMolecular Function: protein C-terminus binding; protein domain specific binding; protein binding; metabotropic glutatmate receptor bindingBiological Process: metabotropic glutamate receptor signaling pathway; protein targeting |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9NSC5 |
| NCBI GenInfo Identifier: | 38605068 |
| NCBI Gene ID: | 9454 |
| NCBI Accession: | Q9NSC5.2 |
| UniProt Secondary Accession: | Q9NSC5 |
| UniProt Related Accession: | Q9NSC5 |
| Molecular Weight: | |
| NCBI Full Name: | Homer protein homolog 3 |
| NCBI Synonym Full Names: | homer scaffold protein 3 |
| NCBI Official Symbol: | HOMER3 |
| NCBI Official Synonym Symbols: | VESL3; HOMER-3 |
| NCBI Protein Information: | homer protein homolog 3 |
| UniProt Protein Name: | Homer protein homolog 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Homer protein |
| UniProt Gene Name: | HOMER3 |
| UniProt Entry Name: | HOME3_HUMAN |
| Antibodies |
| HOMER3 Antibody (PACO09771) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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