Antibody Name:	Hmgcs1 Antibody (PACO37766)
Antibody SKU:	PACO37766
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:	Mouse
Immunogen:	Recombinant Mouse Hydroxymethylglutaryl-CoA synthase, cytoplasmic protein (1-520AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot. All lanes: Hmgcs1 antibody at 12µg/ml. Lane 1: NIH/3T3 whole cell lysate. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 58 kDa. Observed band size: 58 kDa.

Background:	This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Synonyms:	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase), Hmgcs1

UniProt Protein Function:	HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; TransferaseChromosomal Location of Human Ortholog: 13 D2.3\|13Cellular Component: cytoplasm; cytosolMolecular Function: catalytic activity; drug binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; organic acid binding; protein homodimerization activity; transferase activityBiological Process: cholesterol biosynthetic process; cholesterol metabolic process; isoprenoid biosynthetic process; lipid metabolic process; metabolic process; response to low density lipoprotein stimulus; response to purine; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q8JZK9
NCBI GenInfo Identifier:	612339316
NCBI Gene ID:	208715
NCBI Accession:	NP_001278368.1
UniProt Secondary Accession:	Q8JZK9,Q3UXI4
UniProt Related Accession:	Q8JZK9
Molecular Weight:
NCBI Full Name:	hydroxymethylglutaryl-CoA synthase, cytoplasmic
NCBI Synonym Full Names:	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
NCBI Official Symbol:	Hmgcs1
NCBI Official Synonym Symbols:	B130032C06Rik
NCBI Protein Information:	hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Protein Name:	Hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Synonym Protein Names:	3-hydroxy-3-methylglutaryl coenzyme A synthase
Protein Family:
UniProt Gene Name:	Hmgcs1
UniProt Entry Name: