Hmgb1 Antibody

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SKU:
PACO64769
Product Type:
Antibody
Reactivity:
Rat
Applications:
ELISA
Applications:
WB
Conjugation:
Unconjugated
Isotype:
IgG
Host Species:
Rabbit
Research Area:
Immunology

Description

Product Name:Hmgb1 Antibody
Product Code:PACO64769
Size:50µL
Target Names:Hmgb1
Species Reactivity:Rat
Host Species:Rabbit
Antigen Species:Rattus norvegicus (Rat)
Tested Applications:ELISA, WB; Recommended dilution: WB:1:1000-1:5000
Isotype:IgG
Clone ID:N/A
Conjugate:Non-conjugated
Clonality:Polyclonal
Antigen:Recombinant Rat High mobility group protein B1 protein (2-18aa)
Form:Liquid
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Storage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Aliases:High mobility group protein B1 (Amphoterin) (Heparin-binding protein p30) (High mobility group protein 1) (HMG-1), Hmgb1, Hmg-1 Hmg1
Uniprot ID:P63159
Background:Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
Research Area:Others
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