Histone H3 Monoclonal Antibody (CAB22348)

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SKU:
CAB22348
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC
Applications:
IF

Description

Product Name:Histone H3 Monoclonal Antibody
Product Code:CAB22348
Reactivity:Human, Mouse, Rat, Other (Wide Range)
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC50519
Reactivity:Human, Mouse, Rat, Other (Wide Range)
Tested Applications:WB, IHC-P, IF/ICC, IP, ChIP, ELISA, CUT&Tag
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200, ChIP 1:500-1:1000, CUT&Tag 10, ⁵ cells /1 μg
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa, HepG2, Raji, NIH/3T3, Mouse liver, Rat lung
Cellular Location:extracellular exosome, extracellular region, nucleoplasm, nucleus
Customer Validation:WB(Homo sapiens)

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H3 (NP_003520.1).
Sequence:MARTK QTARK STGGK APRKQ LATKA ARKSA PATGG VKKPH RYRPG TVALR EIRRY QKSTE LLIRK LPFQR LVREI AQDFK TDLRF QSSAV MALQE ACEAY
Synonyms:H3/A, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3C10, H3C11, H3C12, HIST1H3A
Calculated MW:15kDa
Observed MW:17kDa
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