| UniProt Protein Function: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P33778 |
| NCBI GenInfo Identifier: | 462236 |
| NCBI Gene ID: | 3018 |
| NCBI Accession: | P33778.2 |
| UniProt Secondary Accession: | P33778,Q4KN36, |
| UniProt Related Accession: | P33778 |
| Molecular Weight: | 13,950 Da |
| NCBI Full Name: | Histone H2B type 1-B |
| NCBI Synonym Full Names: | histone cluster 1 H2B family member b |
| NCBI Official Symbol: | HIST1H2BB |
| NCBI Official Synonym Symbols: | H2B.1; H2B/f; H2BFF |
| NCBI Protein Information: | histone H2B type 1-B |
| UniProt Protein Name: | Histone H2B type 1-B |
| UniProt Synonym Protein Names: | Histone H2B.1; Histone H2B.f; H2B/f |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H2BB |
