HIST3H2A Antibody (PACO09732)
- SKU:
- PACO09732
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HIST3H2A Antibody (PACO09732) |
| Antibody SKU: | PACO09732 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human HIST3H2A |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | histone cluster 3, H2a;HIST3H2A;MGC3165 ; |
| UniProt Protein Function: | HIST3H2A: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1q42.13 Molecular Function:DNA binding Biological Process: chromatin silencing; nucleosome disassembly |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q7L7L0 |
| NCBI GenInfo Identifier: | 74749897 |
| NCBI Gene ID: | 92815 |
| NCBI Accession: | Q7L7L0.3 |
| UniProt Secondary Accession: | Q7L7L0,B2R4S4, |
| UniProt Related Accession: | Q7L7L0 |
| Molecular Weight: | 14,121 Da |
| NCBI Full Name: | Histone H2A type 3 |
| NCBI Synonym Full Names: | histone cluster 3, H2a |
| NCBI Official Symbol: | HIST3H2A |
| NCBI Protein Information: | histone H2A type 3 |
| UniProt Protein Name: | Histone H2A type 3 |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST3H2A |
| UniProt Entry Name: | H2A3_HUMAN |
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