HIST2H2AC Antibody (PACO27377)
- SKU:
- PACO27377
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HIST2H2AC Antibody (PACO27377) |
| Antibody SKU: | PACO27377 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Histone H2A type 2-C protein (2-129AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO27377 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO27377 at dilution of 1:100. |
| Background: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Synonyms: | Histone H2A type 2-C (Histone H2A-GL101) (Histone H2A/q), HIST2H2AC, H2AFQ |
| UniProt Protein Function: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| UniProt Protein Details: | |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q16777 |
| NCBI GenInfo Identifier: | 19557656 |
| NCBI Gene ID: | 8335 |
| NCBI Accession: | NP_003504.2 |
| UniProt Secondary Accession: | Q16777,P0C0S8, P20671, Q16777, Q6FI13, Q7L7L0, Q8IUE6 Q93077, Q96QV6, Q99878 |
| UniProt Related Accession: | Q16777,P04908 |
| Molecular Weight: | 14 |
| NCBI Full Name: | histone H2A type 1-B/E |
| NCBI Synonym Full Names: | histone cluster 1 H2A family member b |
| NCBI Official Symbol: | HIST1H2AB |
| NCBI Official Synonym Symbols: | H2A/m; H2AFM |
| NCBI Protein Information: | histone H2A type 1-B/E |
| UniProt Protein Name: | Histone H2A type 1-B/E |
| UniProt Synonym Protein Names: | Histone H2A.2; Histone H2A/a; Histone H2A/m |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H2AB |
| UniProt Entry Name: |
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