HIST1H2BD Antibody (PACO45898)
- SKU:
- PACO45898
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HIST1H2BD Antibody (PACO45898) |
| Antibody SKU: | PACO45898 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Histone H2B type 1-D protein (2-57AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO45898 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO45898 at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human glioma using PACO45898 at dilution of 1:100. |
| Background: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Synonyms: | Histone H2B type 1-D (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b), HIST1H2BD, H2BFB HIRIP2 |
| UniProt Protein Function: | H2B1D: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Interacts with acetylated H4 during chromatin remodeling. Binds to HIRA, a replication-dependent histone family member.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.3Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: DNA bindingBiological Process: nucleosome assembly |
| UniProt Protein Details: | |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P58876 |
| NCBI GenInfo Identifier: | 21542074 |
| NCBI Gene ID: | 3017 |
| NCBI Accession: | P58876.2 |
| UniProt Secondary Accession: | P58876 |
| UniProt Related Accession: | P58876 |
| Molecular Weight: | 13,936 Da |
| NCBI Full Name: | Histone H2B type 1-D |
| NCBI Synonym Full Names: | histone cluster 1, H2bd |
| NCBI Official Symbol: | HIST1H2BD |
| NCBI Official Synonym Symbols: | H2B/b; H2BFB; H2B.1B; HIRIP2; dJ221C16.6 |
| NCBI Protein Information: | histone H2B type 1-D |
| UniProt Protein Name: | Histone H2B type 1-D |
| UniProt Synonym Protein Names: | HIRA-interacting protein 2; Histone H2B.1 B; Histone H2B.b; H2B/b |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H2BD |
| UniProt Entry Name: | H2B1D_HUMAN |
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