HIPK3 Antibody (PACO53922)
- SKU:
- PACO53922
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HIPK3 Antibody (PACO53922) |
| Antibody SKU: | PACO53922 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Homeodomain-interacting protein kinase 3 protein (841-1130AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human bladder cancer using PACO53922 at dilution of 1:100. |
 | Immunofluorescent analysis of MCF-7 cells using PACO53922 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO53922 at dilution of 1:100. |
| Background: | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
| Synonyms: | Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1), HIPK3, DYRK6 FIST3 PKY |
| UniProt Protein Function: | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H422 |
| NCBI GenInfo Identifier: | 61213741 |
| NCBI Gene ID: | 10114 |
| NCBI Accession: | Q9H422.1 |
| UniProt Secondary Accession: | Q9H422,O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2 |
| UniProt Related Accession: | Q9H422 |
| Molecular Weight: | 131,256 Da |
| NCBI Full Name: | Homeodomain-interacting protein kinase 3 |
| NCBI Synonym Full Names: | homeodomain interacting protein kinase 3 |
| NCBI Official Symbol: | HIPK3 |
| NCBI Official Synonym Symbols: | PKY; YAK1; DYRK6; FIST3 |
| NCBI Protein Information: | homeodomain-interacting protein kinase 3 |
| UniProt Protein Name: | Homeodomain-interacting protein kinase 3 |
| UniProt Synonym Protein Names: | Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; Homolog of protein kinase YAK1 |
| Protein Family: | Homeodomain-interacting protein kinase |
| UniProt Gene Name: | HIPK3 |
| UniProt Entry Name: | HIPK3_HUMAN |
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