HIF-1alpha Monoclonal Antibody
- SKU:
- CAB22041
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | HIF-1alpha Monoclonal Antibody |
| Product Code: | CAB22041 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC0135 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
| Cellular Location: | axon cytoplasm, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus |
| Customer Validation: | WB(Mus musculus, Rattus norvegicus, Homo sapiens)IF(Mus musculus, Gallus gallus)IHC(Homo sapiens, Mus musculus) WB(Gallus gallus)WB，IF(Gallus gallus) IF(Mus musculus) IHC(Rattus norvegicus) IF(Rattus norvegicus) |
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
| Immunogen: | Recombinant protein of human HIF-1alpha |
| Sequence: | Email for sequence |
| Synonyms: | HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF-1-alpha |
| Calculated MW: | 93kDa |
| Observed MW: | 120kDa |
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