HIF-1-alpha Monoclonal Antibody
- SKU:
- CAB24002
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | HIF-1-alpha Monoclonal Antibody |
| Product Code: | CAB24002 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC3208 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Hela+Cobalt chloride, NIH/3T3+Cobalt chloride |
| Cellular Location: | axon cytoplasm, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus |
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-550 of human HIF-1-alpha (NP_001521.1). |
| Sequence: | VTTGQ YRMLA KRGGY VWVET QATVI YNTKN SQPQC IVCVN YVVSG IIQHD LIFSL QQTEC VLKPV ESSDM KMTQL FTKVE SEDTS SLFDK LKKEP DALTL LAPAA GDTII SLDFG SNDTE TDDQQ LEEVP LYNDV MLPSP NEKLQ NINLA MSPLP TAETP KPLRS SADPA LNQEV ALKLE PNPES LELSF TMPQI QDQTP SPSDG STRQS SPEPN SPSEY CFYVD SDMVN EFKLE LVEKL FAEDT EAKNP F |
| Synonyms: | HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF-1-alpha |
| Calculated MW: | 93kDa |
| Observed MW: | 120kDa |
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