Hepatitis B Core Monoclonal Antibody [PPT10E11VN] (CPAB0380)

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SKU:
CPAB0380
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Virus
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PPT10E11VN
Applications:
ELISA

Description

system_update_alt Datasheet
Product Name:Hepatitis B Core antibody
Product Sku:CPAB0380
Size:100μg
Host Species:Mouse
Immunogen:r.HBcAg Core ayw Antigen
Clone:PPT10E11VN.
Reactivity:Viral
Applications:ELISA
Purification Method:
Isotype:IgG2b
Background:Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.
Synonyms:
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
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