Description
system_update_alt Datasheet
Product Name: | HBV AG-2 antibody |
Product Sku: | CPAB0377 |
Size: | 500μg |
Host Species: | mouse |
Immunogen: | r.Hep B vaccine (BTG) |
Clone: | NYRHepB-2. |
Reactivity: | Viral |
Applications: | Immuneprecipitation, Western Blot, ELISA, Immunohistochemistry |
Purification Method: | Ion exchange column. |
Isotype: | IgG1 |
Background: | Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA. |
Synonyms: | |
Storage Buffer: | In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |