Antibody Name:	HA Antibody (PACO33964)
Antibody SKU:	PACO33964
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Influenza A virus(H7N9)
Immunogen:	Recombinant Influenza A virus Hemagglutinin protein (19-524AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Binds to sialic acid, containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Synonyms:

Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain], HA

UniProt Protein Function:	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
UniProt Protein Details:
NCBI Summary:
UniProt Code:	R4NN21
NCBI GenInfo Identifier:	752901097
NCBI Gene ID:	23104227
NCBI Accession:	YP_009118475.1
UniProt Secondary Accession:	R4NN21
UniProt Related Accession:	R4NN21
Molecular Weight:
NCBI Full Name:	hemagglutinin
NCBI Synonym Full Names:
NCBI Official Symbol:	HA
NCBI Official Synonym Symbols:
NCBI Protein Information:	hemagglutinin; HA1; HA2
UniProt Protein Name:	Hemagglutinin
UniProt Synonym Protein Names:
Protein Family:	Protein
UniProt Gene Name:	HA
UniProt Entry Name:	R4NN21_9INFA