Description
Antibody Name: | H2AFY2 Antibody (PACO09659) |
Antibody SKU: | PACO09659 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human H2AFY2 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | H2A histone family, member Y2;H2AFY2;macroH2A2 ; |
UniProt Protein Function: | H2AFY2: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: Barr body; ESC/E(Z) complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm Molecular Function:chromatin DNA binding Biological Process: brain development; chromatin silencing; dosage compensation; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; positive regulation of keratinocyte differentiation; regulation of cell growth |
NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015] |
UniProt Code: | Q9P0M6 |
NCBI GenInfo Identifier: | 12585260 |
NCBI Gene ID: | 55506 |
NCBI Accession: | Q9P0M6.3 |
UniProt Secondary Accession: | Q9P0M6,Q5SQT2, |
UniProt Related Accession: | Q9P0M6 |
Molecular Weight: | 40,058 Da |
NCBI Full Name: | Core histone macro-H2A.2 |
NCBI Synonym Full Names: | H2A histone family member Y2 |
NCBI Official Symbol: | H2AFY2 |
NCBI Official Synonym Symbols: | macroH2A2 |
NCBI Protein Information: | core histone macro-H2A.2 |
UniProt Protein Name: | Core histone macro-H2A.2 |
Protein Family: | Core histone macro |
UniProt Gene Name: | H2AFY2 |
UniProt Entry Name: | H2AW_HUMAN |