H2AFB1 Antibody (PACO27289)
- SKU:
- PACO27289
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | H2AFB1 Antibody (PACO27289) |
| Antibody SKU: | PACO27289 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Histone H2A-Bbd type 1 protein (1-115AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO27289 at dilution of 1:100. |
 | Immunofluorescent analysis of MCF-7 cells using PACO27289 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. |
| Synonyms: | Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd), H2AFB1 |
| UniProt Protein Function: | H2AFB1: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. Belongs to the histone H2A family.Protein type: RNA splicingChromosomal Location of Human Ortholog: Xq28Cellular Component: nucleusMolecular Function: DNA bindingBiological Process: chromatin silencing; mRNA processing; nucleosome assembly |
| UniProt Protein Details: | |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P0C5Y9 |
| NCBI GenInfo Identifier: | 118341725 |
| NCBI Gene ID: | 474382 |
| NCBI Accession: | BC128034 |
| UniProt Secondary Accession: | P0C5Y9,P98176, Q5TZB2, Q6FG78, Q96PR7, A0PK90 |
| UniProt Related Accession: | P0C5Y9 |
| Molecular Weight: | 12,697 Da |
| NCBI Full Name: | Homo sapiens H2A histone family, member B1, mRNA |
| NCBI Synonym Full Names: | H2A histone family member B1 |
| NCBI Official Symbol: | H2AFB1 |
| NCBI Official Synonym Symbols: | H2A.Bbd |
| NCBI Protein Information: | histone H2A-Bbd type 1 |
| UniProt Protein Name: | Histone H2A-Bbd type 1 |
| UniProt Synonym Protein Names: | H2A Barr body-deficient; H2A.Bbd |
| Protein Family: | Histone |
| UniProt Gene Name: | H2AFB1 |
| UniProt Entry Name: | H2AB1_HUMAN |
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