GZMM Antibody (PACO51602)
- SKU:
- PACO51602
Description
| Antibody Name: | GZMM Antibody (PACO51602) |
| Antibody SKU: | PACO51602 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Granzyme M protein (98-243AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO51602 at dilution of 1:100. |
 | Immunofluorescent analysis of MCF-7 cells using PACO51602 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. |
| Synonyms: | Granzyme M (EC 3.4.21) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease), GZMM, MET1 |
| UniProt Protein Function: | GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzyme subfamily. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: membrane Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: cell death |
| NCBI Summary: | Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P51124 |
| NCBI GenInfo Identifier: | 296434527 |
| NCBI Gene ID: | 3004 |
| NCBI Accession: | P51124.2 |
| UniProt Related Accession: | P51124 |
| Molecular Weight: | 27,545 Da |
| NCBI Full Name: | Granzyme M |
| NCBI Synonym Full Names: | granzyme M |
| NCBI Official Symbol: | GZMM |
| NCBI Official Synonym Symbols: | MET1; LMET1 |
| NCBI Protein Information: | granzyme M |
| UniProt Protein Name: | Granzyme M |
| UniProt Synonym Protein Names: | Met-1 serine protease; Hu-Met-1; Met-ase; Natural killer cell granular protease |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMM |
| UniProt Entry Name: | GRAM_HUMAN |
| Antibodies | ELISA Kits |
| GZMM Antibody (PACO07422) | Human Granzyme M ELISA Kit |
| GZMM Antibody (PACO09656) | Human Granzyme M (GZMM) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Host Species: |
Rabbit |
Isotype: |
IgG |
Applications: |
ELISA |
Applications: |
IHC |
Applications: |
IF |
Antibody Type: |
Polyclonal Antibody |
Conjugation: |
Unconjugated |
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