GZMM Antibody (PACO09656)
- SKU:
- PACO09656
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GZMM Antibody (PACO09656) |
| Antibody SKU: | PACO09656 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human GZMM |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | granzyme M (lymphocyte met-ase 1);GZMM;LMET1;MET1 ; |
| UniProt Protein Function: | GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzyme subfamily. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: membrane Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: cell death |
| NCBI Summary: | Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P51124 |
| NCBI GenInfo Identifier: | 296434527 |
| NCBI Gene ID: | 3004 |
| NCBI Accession: | P51124.2 |
| UniProt Related Accession: | P51124 |
| Molecular Weight: | 27,545 Da |
| NCBI Full Name: | Granzyme M |
| NCBI Synonym Full Names: | granzyme M |
| NCBI Official Symbol: | GZMM |
| NCBI Official Synonym Symbols: | MET1; LMET1 |
| NCBI Protein Information: | granzyme M |
| UniProt Protein Name: | Granzyme M |
| UniProt Synonym Protein Names: | Met-1 serine protease; Hu-Met-1; Met-ase; Natural killer cell granular protease |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMM |
| UniProt Entry Name: | GRAM_HUMAN |
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