Guca2b Antibody (PACO27265)
- SKU:
- PACO27265
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Guca2b Antibody (PACO27265) |
| Antibody SKU: | PACO27265 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Guanylate cyclase activator 2B protein (22-106AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. |
| Synonyms: | Guanylate cyclase activator 2B [Cleaved into: Uroguanylin (UGN)], Guca2b |
| UniProt Protein Function: | GUCA2B: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. Belongs to the guanylin family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 4 D2.1|4 55.48 cMCellular Component: photoreceptor outer segmentBiological Process: body fluid secretion; cGMP biosynthetic process; excretion; negative regulation of blood pressure; regulation of cyclic nucleotide biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice for this gene exhibit impaired sodium chloride excretion and elevated arterial pressure. This gene is present in a gene cluster with a related guanylin family member on chromosome 4. [provided by RefSeq, Sep 2015] |
| UniProt Code: | O09051 |
| NCBI GenInfo Identifier: | 160298221 |
| NCBI Gene ID: | 14916 |
| NCBI Accession: | NP_032217.2 |
| UniProt Secondary Accession: | O09051 |
| UniProt Related Accession: | O09051 |
| Molecular Weight: | 36.8kD |
| NCBI Full Name: | guanylate cyclase activator 2B preproprotein |
| NCBI Synonym Full Names: | guanylate cyclase activator 2b (retina) |
| NCBI Official Symbol: | Guca2b |
| NCBI Official Synonym Symbols: | Ugn; Gcap2; AV066530 |
| NCBI Protein Information: | guanylate cyclase activator 2B |
| UniProt Protein Name: | Guanylate cyclase activator 2B |
| UniProt Synonym Protein Names: | |
| Protein Family: | Guanylate cyclase activator |
| UniProt Gene Name: | Guca2b |
| UniProt Entry Name: |
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