Name: GSTT1/GSTT4 Antibody (PACO22347)
SKU: PACO22347
Availability: OutOfStock

Antibody Name:	GSTT1/GSTT4 Antibody (PACO22347)
Antibody SKU:	PACO22347
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human GSTT1/4.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from Jurkat cells, using GSTT1/4 antibody.

Background:	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Synonyms:	EC 2.5.1.18; glutathione S-transferase theta 1; glutathione transferase T1-1; GST class-theta-1;

UniProt Protein Function:	GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family.
UniProt Protein Details:	Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Transferase; EC 2.5.1.18 Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: cytosol Molecular Function:glutathione peroxidase activity; glutathione transferase activity Biological Process: glutathione metabolic process
NCBI Summary:	The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Code:	P30711
NCBI GenInfo Identifier:	21264427
NCBI Gene ID:	2952
NCBI Accession:	P30711.4
UniProt Secondary Accession:	P30711,O00226, Q5TZY2, Q6IC69, Q969K8, Q96IY3,
UniProt Related Accession:	P30711
Molecular Weight:	13,517 Da
NCBI Full Name:	Glutathione S-transferase theta-1
NCBI Synonym Full Names:	glutathione S-transferase theta 1
NCBI Official Symbol:	GSTT1
NCBI Protein Information:	glutathione S-transferase theta-1
UniProt Protein Name:	Glutathione S-transferase theta-1
UniProt Synonym Protein Names:	GST class-theta-1; Glutathione transferase T1-1
Protein Family:	Glutathione S-transferase
UniProt Gene Name:	GSTT1
UniProt Entry Name:	GSTT1_HUMAN