GSTT1/GSTT4 Antibody (PACO00892)

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SKU:
PACO00892
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

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Antibody Name:GSTT1/GSTT4 Antibody
Antibody SKU:PACO00892
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the N-terminal region of human GSTT1/4.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GSTT1; Glutathione S-transferase theta-1; GST class-theta-1; Glutathione transferase T1-1; GSTT4; Glutathione S-transferase theta-4; GST class-theta-4
UniProt Protein Function:GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family.
UniProt Protein Details:

Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Transferase; EC 2.5.1.18

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: cytosol

Molecular Function:glutathione peroxidase activity; glutathione transferase activity

Biological Process: glutathione metabolic process

NCBI Summary:The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Code:P30711
NCBI GenInfo Identifier:21264427
NCBI Gene ID:2952
NCBI Accession:P30711.4
UniProt Secondary Accession:P30711,O00226, Q5TZY2, Q6IC69, Q969K8, Q96IY3,
UniProt Related Accession:P30711
Molecular Weight:13,517 Da
NCBI Full Name:Glutathione S-transferase theta-1
NCBI Synonym Full Names:glutathione S-transferase theta 1
NCBI Official Symbol:GSTT1  
NCBI Protein Information:glutathione S-transferase theta-1
UniProt Protein Name:Glutathione S-transferase theta-1
UniProt Synonym Protein Names:GST class-theta-1; Glutathione transferase T1-1
Protein Family:Glutathione S-transferase
UniProt Gene Name:GSTT1  
UniProt Entry Name:GSTT1_HUMAN
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