GRK7 Antibody (PACO64263)
- SKU:
- PACO64263
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GRK7 Antibody (PACO64263) |
| Antibody SKU: | PACO64263 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | IF:1:100-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rhodopsin kinase protein (342-550AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of Hela cells with PACO64263 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). |
| Synonyms: | Rhodopsin kinase (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7), GRK7, GPRK7 |
| UniProt Protein Function: | GRK7: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
| UniProt Protein Details: | Protein type:EC 2.7.11.14; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.16; AGC group; GRK family; GRK subfamily Chromosomal Location of Human Ortholog: 3q24 Molecular Function:rhodopsin kinase activity Biological Process: protein amino acid autophosphorylation; regulation of rhodopsin mediated signaling |
| NCBI Summary: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WTQ7 |
| NCBI GenInfo Identifier: | 21263659 |
| NCBI Gene ID: | 131890 |
| NCBI Accession: | Q8WTQ7.1 |
| UniProt Related Accession: | Q8WTQ7 |
| Molecular Weight: | 62,212 Da |
| NCBI Full Name: | Rhodopsin kinase |
| NCBI Synonym Full Names: | G protein-coupled receptor kinase 7 |
| NCBI Official Symbol: | GRK7 |
| NCBI Official Synonym Symbols: | GPRK7 |
| NCBI Protein Information: | rhodopsin kinase |
| UniProt Protein Name: | Rhodopsin kinase |
| UniProt Synonym Protein Names: | G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7 |
| Protein Family: | Rhodopsin kinase |
| UniProt Gene Name: | GRK7 |
| UniProt Entry Name: | GRK7_HUMAN |
| Antibodies | ELISA Kits |
| GRK7 Antibody (PACO00888) | GRK7 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
