Description
Antibody Name: | GRHL1 Antibody (PACO61726) |
Antibody SKU: | PACO61726 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Grainyhead-like protein 1 homologprotein (1-95AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate. All lanes: GRHL1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 71, 50, 58 kDa. Observed band size: 71 kDa. | |
IHC image of PACO61726 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO61726 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed. |
Synonyms: | Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32), GRHL1, LBP32 MGR TFCP2L2 |
UniProt Protein Function: | GRHL1: Transcription factor. Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed. May play a role in development. May be involved in epidermal differentiation. Binds and transactivates the EN1 promoter. Belongs to the grh/CP2 family. Grainyhead subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factorChromosomal Location of Human Ortholog: 2p25.1Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleusMolecular Function: chromatin DNA binding; sequence-specific DNA bindingBiological Process: epidermis development; positive regulation of transcription from RNA polymerase II promoter |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009] |
UniProt Code: | Q9NZI5 |
NCBI GenInfo Identifier: | 90101332 |
NCBI Gene ID: | 29841 |
NCBI Accession: | Q9NZI5.2 |
UniProt Secondary Accession: | Q9NZI5,Q53T93, Q6NWN7, Q6NWN8, Q6NWN9, Q8NI33, A6NLA4 B2R7E4, B5MEC2 |
UniProt Related Accession: | Q9NZI5 |
Molecular Weight: | 57,813 Da |
NCBI Full Name: | Grainyhead-like protein 1 homolog |
NCBI Synonym Full Names: | grainyhead like transcription factor 1 |
NCBI Official Symbol: | GRHL1 |
NCBI Official Synonym Symbols: | MGR; NH32; LBP32; TFCP2L2 |
NCBI Protein Information: | grainyhead-like protein 1 homolog |
UniProt Protein Name: | Grainyhead-like protein 1 homolog |
UniProt Synonym Protein Names: | Mammalian grainyhead; NH32; Transcription factor CP2-like 2; Transcription factor LBP-32 |
Protein Family: | Grainyhead-like protein |
UniProt Gene Name: | GRHL1 |
UniProt Entry Name: | GRHL1_HUMAN |