Granzyme K monoclonal antibody (PE) (AGIM0005)
- SKU:
- AGIM0005
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- 24C3
- Conjugation:
- PE
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | Granzyme K monoclonal antibody (PE) |
| Product Code: | AGIM0005 |
| Size: | 500 µL |
| Reactivity: | Human |
| Clone: | 24C3 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P49863 |
| Background: | Granzymes are exogenous serine proteases that are stored in the cytotoxic granules of activated T cells and NK cells. Upon target cell contact, the contents of these granules are directionally exocytosed and, with the assistance of perforin, the granzymes enter the cytosol of the target cell. To date, five human granzymes (A, B, H, K, M) have been described at the molecular genetic level. Human granzyme K (GZMK) is a 28 kD serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specificity cleaving at the basic residues arginine and lysine. To which extent human granzyme K plays a role in the induction of apoptosis in the target cells remains to be evaluated. High mRNA levels of granzyme K are detected in activated T cells and NK cells but are absent in normal tissues that do not contain high numbers of these cells. |
| NCBI Summary: | This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49863 |
| NCBI GenInfo Identifier: | 1708035 |
| NCBI Gene ID: | 3003 |
| NCBI Accession: | P49863.1 |
| UniProt Secondary Accession: | P49863,B2R563, |
| UniProt Related Accession: | P49863 |
| Molecular Weight: | |
| NCBI Full Name: | Granzyme K |
| NCBI Synonym Full Names: | granzyme K |
| NCBI Official Symbol: | GZMK |
| NCBI Official Synonym Symbols: | TRYP2 |
| NCBI Protein Information: | granzyme K |
| UniProt Protein Name: | Granzyme K |
| UniProt Synonym Protein Names: | Fragmentin-3; Granzyme-3; NK-tryptase-2; NK-Tryp-2 |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMK |
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