Description
| Product Name: | Granulin Monoclonal Antibody |
| Product Code: | CAB23230 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC59451 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, Mouse liver |
| Cellular Location: | Secreted, Lysosome |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 494-593 of human Granulin (NP_002078.1). |
| Sequence: | SCEKE VVSAQ PATFL ARSPH VGVKD VECGE GHFCH DNQTC CRDNR QGWAC CPYRQ GVCCA DRRHC CPAGF RCAAR GTKCL RREAP RWDAP LRDPA LRQLL |
| Synonyms: | GEP, GP88, PEPI, PGRN, CLN11, PCDGF |
| Calculated MW: | 64kDa |
| Observed MW: | 75-88kDa |
