Name: GPS2 Antibody (PACO53666)
SKU: PACO53666
Availability: OutOfStock

Antibody Name:	GPS2 Antibody (PACO53666)
Antibody SKU:	PACO53666
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human G protein pathway suppressor 2 protein (1-327AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Immunofluorescent analysis of Hela cells using PACO53666 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Background:	Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Synonyms:	G protein pathway suppressor 2 (GPS-2), GPS2

UniProt Protein Function:	GPS2: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Inhibitor; G protein regulator, misc.; Cell cycle regulationChromosomal Location of Human Ortholog: 17p13Cellular Component: nucleoplasm; transcriptional repressor complexMolecular Function: protein binding; transcription corepressor activity; GTPase inhibitor activityBiological Process: negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; cell cycle; inactivation of MAPK activity
UniProt Protein Details:
NCBI Summary:	This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
UniProt Code:	Q13227
NCBI GenInfo Identifier:	6226623
NCBI Gene ID:	2874
NCBI Accession:	Q13227.3
UniProt Secondary Accession:	Q13227,Q6FHM8, B4DXA1
UniProt Related Accession:	Q13227
Molecular Weight:	37kDa
NCBI Full Name:	G protein pathway suppressor 2
NCBI Synonym Full Names:	G protein pathway suppressor 2
NCBI Official Symbol:	GPS2
NCBI Official Synonym Symbols:	AMF-1
NCBI Protein Information:	G protein pathway suppressor 2; GPS-2
UniProt Protein Name:	G protein pathway suppressor 2
UniProt Synonym Protein Names:
Protein Family:	G protein pathway suppressor
UniProt Gene Name:	GPS2
UniProt Entry Name:	GPS2_HUMAN