GPS2 Antibody (PACO53666)
- SKU:
- PACO53666
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GPS2 Antibody (PACO53666) |
| Antibody SKU: | PACO53666 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human G protein pathway suppressor 2 protein (1-327AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of Hela cells using PACO53666 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
| Synonyms: | G protein pathway suppressor 2 (GPS-2), GPS2 |
| UniProt Protein Function: | GPS2: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Inhibitor; G protein regulator, misc.; Cell cycle regulationChromosomal Location of Human Ortholog: 17p13Cellular Component: nucleoplasm; transcriptional repressor complexMolecular Function: protein binding; transcription corepressor activity; GTPase inhibitor activityBiological Process: negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; cell cycle; inactivation of MAPK activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13227 |
| NCBI GenInfo Identifier: | 6226623 |
| NCBI Gene ID: | 2874 |
| NCBI Accession: | Q13227.3 |
| UniProt Secondary Accession: | Q13227,Q6FHM8, B4DXA1 |
| UniProt Related Accession: | Q13227 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | G protein pathway suppressor 2 |
| NCBI Synonym Full Names: | G protein pathway suppressor 2 |
| NCBI Official Symbol: | GPS2 |
| NCBI Official Synonym Symbols: | AMF-1 |
| NCBI Protein Information: | G protein pathway suppressor 2; GPS-2 |
| UniProt Protein Name: | G protein pathway suppressor 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | G protein pathway suppressor |
| UniProt Gene Name: | GPS2 |
| UniProt Entry Name: | GPS2_HUMAN |
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