GPR39 Antibody (PACO54798)
- SKU:
- PACO54798
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GPR39 Antibody (PACO54798) |
| Antibody SKU: | PACO54798 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human G-protein coupled receptor 39 protein (345-453AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO54798 at dilution of 1:100. |
 | Immunofluorescence staining of HepG2 cells with PACO54798 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-α and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). |
| Synonyms: | G-protein coupled receptor 39, GPR39 |
| UniProt Protein Function: | GPR39: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integralChromosomal Location of Human Ortholog: 2q21-q22Cellular Component: integral to plasma membrane; plasma membrane |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016] |
| UniProt Code: | O43194 |
| NCBI GenInfo Identifier: | 3913748 |
| NCBI Gene ID: | 2863 |
| NCBI Accession: | O43194.1 |
| UniProt Secondary Accession: | O43194,Q08AS2, Q53R01, B2RC12, B6V9G4 |
| UniProt Related Accession: | O43194 |
| Molecular Weight: | 51,329 Da |
| NCBI Full Name: | G-protein coupled receptor 39 |
| NCBI Synonym Full Names: | G protein-coupled receptor 39 |
| NCBI Official Symbol: | GPR39 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | G-protein coupled receptor 39 |
| UniProt Protein Name: | G-protein coupled receptor 39 |
| UniProt Synonym Protein Names: | |
| Protein Family: | G-protein coupled receptor |
| UniProt Gene Name: | GPR39 |
| UniProt Entry Name: | GPR39_HUMAN |
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