GPR161 Antibody (PACO31804)
- SKU:
- PACO31804
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GPR161 Antibody (PACO31804) |
| Antibody SKU: | PACO31804 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human G-protein coupled receptor 161 protein (1-28AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: GPR161 antibody at 2µg/ml + EC109 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 59, 46, 44, 50, 47, 61 kDa Observed band size: 30 kDa . |
 | Immunofluorescent analysis of Hela cells using PACO31804 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). |
| Synonyms: | G-protein coupled receptor 161 (G-protein coupled receptor RE2), GPR161 |
| UniProt Protein Function: | GPR161: Orphan receptor. Plays a role in neurulation and lens development. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of Human Ortholog: 1q24.2Cellular Component: cilium; recycling endosomeMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017] |
| UniProt Code: | Q8N6U8 |
| NCBI GenInfo Identifier: | 390190202 |
| NCBI Gene ID: | 23432 |
| NCBI Accession: | NP_001254538.1 |
| UniProt Secondary Accession: | Q8N6U8,O75963, Q5TGK0, Q5TGK1, Q5TGK2, B3KV34, B7Z5D7 B7Z5E8, B7Z5Z6, F5GXD6 |
| UniProt Related Accession: | Q8N6U8 |
| Molecular Weight: | 30.4kD |
| NCBI Full Name: | G-protein coupled receptor 161 isoform 1 |
| NCBI Synonym Full Names: | G protein-coupled receptor 161 |
| NCBI Official Symbol: | GPR161 |
| NCBI Official Synonym Symbols: | RE2 |
| NCBI Protein Information: | G-protein coupled receptor 161 |
| UniProt Protein Name: | G-protein coupled receptor 161 |
| UniProt Synonym Protein Names: | G-protein coupled receptor RE2 |
| Protein Family: | G-protein coupled receptor |
| UniProt Gene Name: | GPR161 |
| UniProt Entry Name: |
| Antibodies |
| GPR161 Antibody (PACO09562) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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