GPM6B Antibody (PACO35366)
- SKU:
- PACO35366
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GPM6B Antibody (PACO35366) |
| Antibody SKU: | PACO35366 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Neuronal membrane glycoprotein M6-b protein (1-64AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: GPM6B antibody at 5µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 29, 27, 34, 37 kDa. Observed band size: 29 kDa. |
 | Immunofluorescent analysis of HepG2 cells using PACO35366 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO35366 at dilution of 1:100. |
| Background: | May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. |
| Synonyms: | Neuronal membrane glycoprotein M6-b (M6b), GPM6B, M6B |
| UniProt Protein Function: | GPM6B: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. Belongs to the myelin proteolipid protein family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: Xp22.2Cellular Component: lipid raft; plasma membraneBiological Process: negative regulation of serotonin uptake; positive regulation of bone mineralization; regulation of actin cytoskeleton organization and biogenesis; regulation of focal adhesion formation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q13491 |
| NCBI GenInfo Identifier: | 20141466 |
| NCBI Gene ID: | 2824 |
| NCBI Accession: | Q13491.2 |
| UniProt Secondary Accession: | Q13491,O76077, Q86X43, Q8N956 |
| UniProt Related Accession: | Q13491 |
| Molecular Weight: | 36,220 Da |
| NCBI Full Name: | Neuronal membrane glycoprotein M6-b |
| NCBI Synonym Full Names: | glycoprotein M6B |
| NCBI Official Symbol: | GPM6B |
| NCBI Official Synonym Symbols: | M6B |
| NCBI Protein Information: | neuronal membrane glycoprotein M6-b |
| UniProt Protein Name: | Neuronal membrane glycoprotein M6-b |
| UniProt Synonym Protein Names: | |
| Protein Family: | Neuronal membrane glycoprotein |
| UniProt Gene Name: | GPM6B |
| UniProt Entry Name: | GPM6B_HUMAN |
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