GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)
![GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58432/63614/gnmt-monoclonal-antibody-pat3f6at-cpab0206__64875__29813.1706535009.jpg?c=1 "GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)")
- SKU:
- CPAB0206
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- PAT3F6AT
- Applications:
- WB
- Applications:
- ELISA
- Applications:
- FC
![GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58432/63614/gnmt-monoclonal-antibody-pat3f6at-cpab0206__64875__29813.1706535009.jpg?c=1&imbypass=on "GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)")
Description
system_update_alt Datasheet
| Product Name: | GNMT Antibody |
| Product Sku: | CPAB0206 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human GNMT mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GNMT amino acids 44-51 purified from Ecoli. |
| Clone: | PAT3F6AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA, Flow Cytometry |
| Purification Method: | GNMT antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. |
| Isotype: | IgG2a |
| Background: | GNMT is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine with glycine to S-adenosyl-L-homocysteine and sarcosine. GNMT is located in the cytoplasm and acts as a homotetramer. Defects in the GNMT gene causes of GNMT deficiency (hypermethioninemia). GNMT affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and is involved in the detoxification pathway in liver cells. GNMT expression is diminished in human hepatocellular carcinoma (HCC). GNMT catalyzes the methylation of glycine by using s- adenosylmethionine (adomet) to form n-methylglycine (sarcosine) with the concomitant production of s-adenosylhomocysteine (adohcy). GNMT plays an essential role in the regulation of tissue concentration of adomet and of metabolism of methionine. |
| Synonyms: | Glycine N-methyltransferase, GNMT. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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