GMFB Monoclonal Antibody [PAT44D8AT] (CPAB0083)
![GMFB Monoclonal Antibody [PAT44D8AT] (CPAB0083)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58311/63493/gmfb-monoclonal-antibody-pat44d8at-cpab0083__13193__11690.1706534967.jpg?c=1 "GMFB Monoclonal Antibody [PAT44D8AT] (CPAB0083)")
- SKU:
- CPAB0083
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- PAT44D8AT
- Applications:
- WB
- Applications:
- ELISA
![GMFB Monoclonal Antibody [PAT44D8AT] (CPAB0083)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58311/63493/gmfb-monoclonal-antibody-pat44d8at-cpab0083__13193__11690.1706534967.jpg?c=1&imbypass=on "GMFB Monoclonal Antibody [PAT44D8AT] (CPAB0083)")
Description
system_update_alt Datasheet
| Product Name: | GMFB Antibody |
| Product Sku: | CPAB0083 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human GMFB mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GMFB amino acids 1-142 purified from Ecoli. |
| Clone: | PAT44D8AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | GMFB antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. |
| Isotype: | IgG2a |
| Background: | Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa protein nerve gorwth factor identified as a growth and differentiation factor in the vertebrate brain. Glia Maturation Factor-Beta stimulates differentiation of normal neurons as well as glial cells. GMFB inhibits the proliferation of the N-18 neuroblastoma line and the C6 glioma line while promoting their phenotypic expression. GMF-beta inhances the phenotypic expression of glia & neurons thus inhibits the proliferation of their respective tumors when added to cell culture. Although astrocytes produce GMF-b and stores it inside the cells, they dont secrete the GMF-B into the cultured medium. Cell- surface GMFb acts on the target cells at close range when cells are in direct contact. GMF-Beta is produced by thymic epithelial cells and plays an important role in T cell development in favor of CD4+ T cells. GMF-Beta is a brain-specific protein which belongs to the actin-binding proteins (ADF) family. GMF-beta appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines. |
| Synonyms: | Glia maturation factor beta, GMFB, GMF-B, GMF-beta, GMF. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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