GluR2/GRIA2 Monoclonal Antibody
- SKU:
- CAB22128
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | GluR2/GRIA2 Monoclonal Antibody |
| Product Code: | CAB22128 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53741 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000,-1:10000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Rat brain |
| Cellular Location: | Cell membrane, Endoplasmic reticulum membrane, Postsynaptic cell membrane, Postsynaptic density membrane |
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-470 of human GluR2/GRIA2 (NP_001077088.2). |
| Sequence: | CLANP AVPWG QGVEI ERALK QVQVE GLSGN IKFDQ NGKRI NYTIN IMELK TNGPR KIGYW SEVDK MVVTL TELPS GNDTS GLENK TVVVT TILES PYVMM KKNHE MLEGN ERYEG YCVDL AAEIA KHCGF KYKLT IVGDG K |
| Synonyms: | GLUR2, GLURB, GluA2, HBGR2, NEDLIB, gluR-2, gluR-B, GluR-K2 |
| Calculated MW: | 99kDa |
| Observed MW: | 100kDa |
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