Glucocorticoid Receptor Polyclonal Antibody
- SKU:
- CAB21442
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | Glucocorticoid Receptor Polyclonal Antibody |
| Product Code: | CAB21442 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Mitochondrion, Nucleus, Nucleus |
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Glucocorticoid Receptor (NP_001191194.1). |
| Sequence: | MDSKE SLTPG REENP SSVLA QERGD VMDFY KTLRG GATVK VSASS PSLAV ASQSD SKQRR LLVDF PKGSV SNAQQ PDLSK AVSLS MGLYM GETET KVMGN DLGFP QQGQI SLSSG ETDLK LLEES IANLN RSTSV PENPK SSAST AVSAA PTEKE FPKTH SDVSS EQQHL KGQTG TNGGN VKLYT TDQST FDILQ DLEFS SGSPG KETNE SPWRS DLLID ENCLL SPLAG EDDSF LLEGN SNEDC KPLIL PDTKP KIKDN GDLVL SSPSN VTLPQ VKTEK |
| Synonyms: | GR, GCR, GRL, GCCR, GCRST |
| Calculated MW: | 86kDa |
| Observed MW: | Refer to figures |
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