Description
Antibody Name: | GJA3 Antibody |
Antibody SKU: | PACO03869 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Connexin 46. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | GJA3; Gap junction alpha-3 protein; Connexin-46; Cx46 |
UniProt Protein Function: | GJA3: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in GJA3 are a cause of cataract autosomal dominant (ADC). Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Belongs to the connexin family. Alpha-type (group II) subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 13q12.11Biological Process: cell-cell signaling; visual perceptionDisease: Cataract 14, Multiple Types |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9Y6H8 |
NCBI GenInfo Identifier: | 311033478 |
NCBI Gene ID: | 2700 |
NCBI Accession: | Q9Y6H8.4 |
UniProt Secondary Accession: | Q9Y6H8,Q0VAB7, Q9H537 |
UniProt Related Accession: | Q9Y6H8 |
Molecular Weight: | 47,410 Da |
NCBI Full Name: | Gap junction alpha-3 protein |
NCBI Synonym Full Names: | gap junction protein alpha 3 |
NCBI Official Symbol: | GJA3 |
NCBI Official Synonym Symbols: | CX46; CZP3; CTRCT14 |
NCBI Protein Information: | gap junction alpha-3 protein |
UniProt Protein Name: | Gap junction alpha-3 protein |
UniProt Synonym Protein Names: | Connexin-46; Cx46 |
Protein Family: | Gap junction alpha-3 protein |
UniProt Gene Name: | GJA3 |
UniProt Entry Name: | CXA3_HUMAN |