GINS1 Antibody (PACO58128)
- SKU:
- PACO58128
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GINS1 Antibody (PACO58128) |
| Antibody SKU: | PACO58128 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DNA replication complex GINS protein PSF1 protein (1-196AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58128 diluted at 1:400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO58128 diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function. |
| Synonyms: | DNA replication complex GINS protein PSF1 (GINS complex subunit 1), GINS1, KIAA0186 PSF1 |
| UniProt Protein Function: | GINS1: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function. Belongs to the GINS1/PSF1 family.Protein type: Motility/polarity/chemotaxis; DNA replicationChromosomal Location of Human Ortholog: 20p11.21Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: 3'-5' DNA helicase activityBiological Process: DNA strand elongation during DNA replication |
| UniProt Protein Details: | |
| NCBI Summary: | The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q14691 |
| NCBI GenInfo Identifier: | 6226339 |
| NCBI Gene ID: | 9837 |
| NCBI Accession: | Q14691.1 |
| UniProt Secondary Accession: | Q14691,Q9NQE2, Q9NQI7 |
| UniProt Related Accession: | Q14691 |
| Molecular Weight: | 22,988 Da |
| NCBI Full Name: | DNA replication complex GINS protein PSF1 |
| NCBI Synonym Full Names: | GINS complex subunit 1 |
| NCBI Official Symbol: | GINS1 |
| NCBI Official Synonym Symbols: | PSF1 |
| NCBI Protein Information: | DNA replication complex GINS protein PSF1 |
| UniProt Protein Name: | DNA replication complex GINS protein PSF1 |
| UniProt Synonym Protein Names: | GINS complex subunit 1 |
| Protein Family: | Probable DNA replication complex GINS protein |
| UniProt Gene Name: | GINS1 |
| UniProt Entry Name: | PSF1_HUMAN |
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