GIMAP4 Antibody (PACO62627)
- SKU:
- PACO62627
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GIMAP4 Antibody (PACO62627) |
| Antibody SKU: | PACO62627 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human GTPase IMAP family member 4 protein (5-101AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO62627 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. |
| Synonyms: | GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4), GIMAP4, IAN1 IMAP4 |
| UniProt Protein Function: | GIMAP4: May play a role in regulating lymphocyte apoptosis. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. Belongs to the IAN GTP-binding protein family.Protein type: HydrolaseChromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytosolMolecular Function: GTP binding |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NUV9 |
| NCBI GenInfo Identifier: | 8922873 |
| NCBI Gene ID: | 55303 |
| NCBI Accession: | NP_060796.1 |
| UniProt Secondary Accession: | Q9NUV9 |
| UniProt Related Accession: | Q9NUV9 |
| Molecular Weight: | 37,534 Da |
| NCBI Full Name: | GTPase IMAP family member 4 |
| NCBI Synonym Full Names: | GTPase, IMAP family member 4 |
| NCBI Official Symbol: | GIMAP4 |
| NCBI Official Synonym Symbols: | IAN1; IAN-1; IMAP4; MSTP062 |
| NCBI Protein Information: | GTPase IMAP family member 4 |
| UniProt Protein Name: | GTPase IMAP family member 4 |
| UniProt Synonym Protein Names: | Immunity-associated nucleotide 1 protein; IAN-1; hIAN1; Immunity-associated protein 4 |
| Protein Family: | GTPase IMAP family |
| UniProt Gene Name: | GIMAP4 |
| UniProt Entry Name: | GIMA4_HUMAN |
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