Antibody Name:	gH Antibody (PACO34150)
Antibody SKU:	PACO34150
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Human cytomegalovirus
Immunogen:	Recombinant Human cytomegalovirus Envelope glycoprotein H protein (24-195AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). In human cytomegalovirus, forms two distincts complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA. The gH-gL-UL128-UL130-UL131A pentamer is essential for viral entry in epithelial, endothelial and myeloid cells via interaction with host NRP2 (By similarity).

Synonyms:

Envelope glycoprotein H (gH), gH, UL75

UniProt Protein Function:	The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P12824
NCBI GenInfo Identifier:	138313
NCBI Gene ID:
NCBI Accession:	P12824.1
UniProt Secondary Accession:	P12824,Q7M6L7
UniProt Related Accession:	P12824
Molecular Weight:	21.8 kDa
NCBI Full Name:	Envelope glycoprotein H
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:	Envelope glycoprotein H
UniProt Synonym Protein Names:
Protein Family:	Envelope glycoprotein
UniProt Gene Name:	gH
UniProt Entry Name:	GH_HCMVA