GFRAL Antibody (PACO36906)
- SKU:
- PACO36906
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GFRAL Antibody (PACO36906) |
| Antibody SKU: | PACO36906 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human GDNF family receptor alpha-like protein (19-351AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, Mouse stomach tissue. All lanes: GFRAL antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa. |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO36906 at dilution of 1:100. |
| Background: | Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. |
| Synonyms: | GDNF family receptor alpha-like, GFRAL, C6orf144 |
| UniProt Protein Function: | GFRAL: Belongs to the GDNFR family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p12.1Cellular Component: integral to membrane; intracellular; plasma membraneBiological Process: negative regulation of neuron apoptosis; stress-activated protein kinase signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6UXV0 |
| NCBI GenInfo Identifier: | 148231468 |
| NCBI Gene ID: | 389400 |
| NCBI Accession: | NP_997293.2 |
| UniProt Secondary Accession: | Q6UXV0,Q5VTF6 |
| UniProt Related Accession: | Q6UXV0 |
| Molecular Weight: | |
| NCBI Full Name: | GDNF family receptor alpha-like |
| NCBI Synonym Full Names: | GDNF family receptor alpha like |
| NCBI Official Symbol: | GFRAL |
| NCBI Official Synonym Symbols: | GRAL; UNQ9356; C6orf144; bA360D14.1 |
| NCBI Protein Information: | GDNF family receptor alpha-like |
| UniProt Protein Name: | GDNF family receptor alpha-like |
| UniProt Synonym Protein Names: | |
| Protein Family: | GDNF family receptor |
| UniProt Gene Name: | GFRAL |
| UniProt Entry Name: | GFRAL_HUMAN |
