GFRA4 Antibody (PACO18432)
- SKU:
- PACO18432
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GFRA4 Antibody (PACO18432) |
| Antibody SKU: | PACO18432 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human GFRA4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18432(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18432(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Synonyms: | GDNF family receptor α 4 |
| UniProt Protein Function: | GFRA4: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Belongs to the GDNFR family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 20p13-p12Cellular Component: plasma membraneMolecular Function: Ras guanyl-nucleotide exchange factor activityBiological Process: MAPKKK cascade |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9GZZ7 |
| NCBI GenInfo Identifier: | 30173123 |
| NCBI Gene ID: | 64096 |
| NCBI Accession: | Q9GZZ7.2 |
| UniProt Secondary Accession: | Q9GZZ7,Q5JT74, Q9H191, Q9H192 |
| UniProt Related Accession: | Q9GZZ7 |
| Molecular Weight: | 19,216 Da |
| NCBI Full Name: | GDNF family receptor alpha-4 |
| NCBI Synonym Full Names: | GDNF family receptor alpha 4 |
| NCBI Official Symbol: | GFRA4 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | GDNF family receptor alpha-4 |
| UniProt Protein Name: | GDNF family receptor alpha-4 |
| UniProt Synonym Protein Names: | Persephin receptor |
| Protein Family: | GDNF family receptor |
| UniProt Gene Name: | GFRA4 |
| UniProt Entry Name: | GFRA4_HUMAN |
| Antibodies |
| GFRA4 Antibody (PACO05013) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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