Gfer Antibody (PACO49210)
- SKU:
- PACO49210
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Gfer Antibody (PACO49210) |
| Antibody SKU: | PACO49210 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat FAD-linked sulfhydryl oxidase ALR protein (1-198AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis. |
| Synonyms: | FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration), Gfer, Alr |
| UniProt Protein Function: | Function: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis.1 PublicationManual assertion based on experiment in:Ref.1Catalytic activity: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.Cofactor: FAD.1 PublicationManual assertion based on experiment in:Ref.3 |
| UniProt Protein Details: | |
| NCBI Summary: | protein that augments liver regeneration [RGD, Feb 2006] |
| UniProt Code: | Q63042 |
| NCBI GenInfo Identifier: | 347800639 |
| NCBI Gene ID: | 27100 |
| NCBI Accession: | NP_037354.2 |
| UniProt Secondary Accession: | Q63042 |
| UniProt Related Accession: | Q63042 |
| Molecular Weight: | 22,837 Da |
| NCBI Full Name: | FAD-linked sulfhydryl oxidase ALR |
| NCBI Synonym Full Names: | growth factor, augmenter of liver regeneration |
| NCBI Official Symbol: | Gfer |
| NCBI Official Synonym Symbols: | ALR |
| NCBI Protein Information: | FAD-linked sulfhydryl oxidase ALR; growth factor, erv1 homolog; augmenter of liver regeneration; growth factor, erv1-like (augmenter of liver regeneration) |
| UniProt Protein Name: | FAD-linked sulfhydryl oxidase ALR |
| UniProt Synonym Protein Names: | Augmenter of liver regeneration |
| Protein Family: | FAD-linked sulfhydryl oxidase |
| UniProt Gene Name: | Gfer |
| UniProt Entry Name: | ALR_RAT |
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