Genome polyprotein Antibody (PACO33948)
- SKU:
- PACO33948
- Product Type:
- Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Genome polyprotein Antibody (PACO33948) |
| Antibody SKU: | PACO33948 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Dengue virus type 1 |
| Immunogen: | Recombinant Dengue virus type 1 Genome polyprotein protein |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA.prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acid, c pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated. |
| Synonyms: | Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)] |
| UniProt Protein Function: | Capsid protein C: Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle (PubMed:11893341). During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions (PubMed:18420804, PubMed:21909430). Overcomes the anti-viral effects of host EXOC1 by sequestering and degrading the latter through the proteasome degradation pathway (PubMed:23522008). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P17763 |
| NCBI GenInfo Identifier: | 9626686 |
| NCBI Gene ID: | 5075725 |
| NCBI Accession: | NP_059433.1 |
| UniProt Secondary Accession: | P17763,P27910, P89313, P89314 |
| UniProt Related Accession: | P17763 |
| Molecular Weight: | 378,702 Da |
| NCBI Full Name: | flavivirus polyprotein |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | flavivirus polyprotein gene |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | flavivirus polyprotein; anchored capsid protein C; membrane glycoprotein precursor M; membrane glycoprotein M; envelope protein E; nonstructural protein NS1; nonstructural protein NS2A; nonstructural protein NS2B; nonstructural protein NS3; nonstructural protein NS4A; nonstructural protein NS4B; RNA-dependent RNA polymerase NS5; protein 2K |
| UniProt Protein Name: | Genome polyprotein |
| UniProt Synonym Protein Names: | Non-structural protein 5 |
| Protein Family: | Genome polyprotein |
| UniProt Gene Name: | NS4A |
| UniProt Entry Name: |
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