Antibody Name:	Genome polyprotein Antibody (PACO33948)
Antibody SKU:	PACO33948
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Dengue virus type 1
Immunogen:	Recombinant Dengue virus type 1 Genome polyprotein protein

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA.prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acid, c pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.

Synonyms:

Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]

UniProt Protein Function:	Capsid protein C: Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle (PubMed:11893341). During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions (PubMed:18420804, PubMed:21909430). Overcomes the anti-viral effects of host EXOC1 by sequestering and degrading the latter through the proteasome degradation pathway (PubMed:23522008).
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P17763
NCBI GenInfo Identifier:	9626686
NCBI Gene ID:	5075725
NCBI Accession:	NP_059433.1
UniProt Secondary Accession:	P17763,P27910, P89313, P89314
UniProt Related Accession:	P17763
Molecular Weight:	378,702 Da
NCBI Full Name:	flavivirus polyprotein
NCBI Synonym Full Names:
NCBI Official Symbol:	flavivirus polyprotein gene
NCBI Official Synonym Symbols:
NCBI Protein Information:	flavivirus polyprotein; anchored capsid protein C; membrane glycoprotein precursor M; membrane glycoprotein M; envelope protein E; nonstructural protein NS1; nonstructural protein NS2A; nonstructural protein NS2B; nonstructural protein NS3; nonstructural protein NS4A; nonstructural protein NS4B; RNA-dependent RNA polymerase NS5; protein 2K
UniProt Protein Name:	Genome polyprotein
UniProt Synonym Protein Names:	Non-structural protein 5
Protein Family:	Genome polyprotein
UniProt Gene Name:	NS4A
UniProt Entry Name: