GenieFluor Violet 450 Anti-Mouse IL-17A Antibody [17F3] (AGEL3129)

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SKU:
AGEL3129
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
ICFCM
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
17F3
Conjugation:
AFViolet 450

Description

Product Name:GenieFluor Violet 450 Anti-Mouse IL-17A Antibody [17F3] (AGEL3129)
Product Code:AGEL3129
Clone No:17F3
Synonyms:Interleukin-17A,Il17a,Ctla8
Reactivity:Mouse
Host Species:Mouse
Applications:ICFCM
Isotype:Mouse IgG1, κ
Isotype Control:GenieFluor Violet 450 Mouse IgG2a, κ Isotype Control [C1.18.4] (AGEL2855)
Conjugation:AFViolet 450
Form:Liquid
Fluorescent Label:AFViolet 450 is designed to be excited by the violet laser (405 nm) and detected using an optical filter centered near 450 nm (e.g., a 450/45 nm bandpass filter).
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Gene ID:16171
Swissprot:Q62386
Stability & Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-49A in vivo.

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