GenieFluor Violet 450 Anti-Human/Mouse CD44 Antibody [IM7] (AGEL2735)

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SKU:
AGEL2735
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2b, κ
Clone:
IM7
Conjugation:
AFViolet 450

Description

Product Name:GenieFluor Violet 450 Anti-Human/Mouse CD44 Antibody [IM7] (AGEL2735)
Product Code:AGEL2735
Clone No:IM7
Synonyms:CD44 antigen,CD44,CDw44,Epican,Phagocytic glycoprotein 1,PGP-1,Phagocytic glycoprotein I,PGP-I,CD44,LHR, MDU2, MDU3, MIC4
Reactivity:Human,Mouse
Host Species:Rat
Applications:FCM
Isotype:Rat IgG2b, κ
Isotype Control:GenieFluor Violet 450 Rat IgG2b, κ Isotype Control [LTF-2] (AGEL2863)
Conjugation:AFViolet 450
Form:Liquid
Fluorescent Label:AFViolet 450 is designed to be excited by the violet laser (405 nm) and detected using an optical filter centered near 450 nm (e.g., a 450/45 nm bandpass filter).
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Gene ID:12505960
Swissprot:P15379,P16070
Stability & Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

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