GenieFluor Red 780 Anti-Human CD8a Antibody [OKT-8]

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SKU:
AGEL2979
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG2a, κ
Clone:
OKT-8
Conjugation:
AFRed 780

Description

Product Name:GenieFluor Red 780 Anti-Human CD8a Antibody [OKT-8]
Product Code:AGEL2979
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL
Reactivity:Human
Host Species:Mouse
Applications:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:GenieFluor Red 780 Mouse IgG2a, κ Isotype Control [C1.18.4] (AGEL2922)
Conjugation:AFRed 780
Form:Liquid
Fluorescent Label:AFRed 780 is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 770 nm (e.g., a 780/60 nm bandpass filter).
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Gene ID:925
Swissprot:P01732
Stability & Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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