GenieFluor 647 Anti-Mouse IL-17A Antibody [TC11-18H10.1] (AGEL2757)

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SKU:
AGEL2757
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
ICFCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, κ
Clone:
TC11-18H10.1
Conjugation:
AF647

Description

Product Name:GenieFluor 647 Anti-Mouse IL-17A Antibody [TC11-18H10.1] (AGEL2757)
Product Code:AGEL2757
Clone No:TC11-18H10.1
Synonyms:Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8
Reactivity:Mouse
Host Species:Rat
Applications:ICFCM
Isotype:Rat IgG1, κ
Isotype Control:GenieFluor 647 Rat IgG2a, κ Isotype Control [2A3] (AGEL2651)
Conjugation:AF647
Form:Liquid
Fluorescent Label:AF647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter).
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Swissprot:Q62386
Stability & Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

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