GenieFluor 647 Anti-Mouse CD150 Antibody [TC15-12F12.2] (AGEL3370)

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SKU:
AGEL3370
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, λ
Clone:
TC15-12F12.2
Conjugation:
AF647

Description

Product Name:AF647 Anti-Mouse CD150 Antibody [TC15-12F12.2]
Product Code:AGEL3370
Size:50 Tests, 100 Tests, 200 Tests
Clone No:TC15-12F12.2
Synonyms:Slam, Slamf1, CD 150, Signaling lymphocytic activation molecule
Reactivity:Mouse
Host Species:Rat
Applications:FCM
Isotype:Rat IgG2a, λ
Isotype Control:APC/Cyanine5.5 Rat IgG2a, λ Isotype Control [B39-4]
Conjugation:AF647
Applications:FCM
Recommended Dilution:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Fluorescent Label:GenieFluor 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter).
Shipping:Biological ice pack at 4°C
Form:Liquid
Gene ID:27218
Swissprot:Q9QUM4
Background Information:CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.
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