GenieFluor 488 Anti-Human CD8a Antibody [HIT8a]

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SKU:
AGEL3393
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
HIT8a
Conjugation:
AF488

Description

Product Name:AF488 Anti-Human CD8a Antibody [HIT8a]
Product Code:AGEL3393
Size:20 Tests, 100 Tests, 200 Tests
Clone No:HIT8a
Synonyms:T-cell surface glycoprotein CD8 alpha chain, CD8A, T8, Leu2, MAL
Reactivity:Human
Host Species:Mouse
Applications:FCM
Isotype:Mouse IgG1, κ
Isotype Control:AF488 Mouse IgG1, κ Isotype Control [MOPC-21]
Conjugation:AF488
Applications:FCM
Recommended Dilution:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Fluorescent Label:GenieFluor 488 is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 520 nm (e.g., a 525/40 nm bandpass filter).
Shipping:Biological ice pack at 4°C
Form:Liquid
Gene ID:925
Swissprot:P01732
Background Information:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
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